All-trans retinoic acid induces synaptic plasticity in human cortical neurons

Maximilian Lenz, Pia Kruse, Amelie Eichler, Jakob Straehle, Jürgen Beck, Thomas Deller & Andreas Vlachos
A defining feature of the brain is the ability of its synaptic contacts to adapt structurally and functionally in an experience-dependent manner. In the human cortex, however, direct experimental evidence for coordinated structural and functional synaptic adaptation is currently lacking. Here, we probed synaptic plasticity in human cortical slices using the vitamin A derivative all-trans retinoic acid (atRA), a putative treatment for neuropsychiatric disorders such as Alzheimer’s disease. Our experiments demonstrated that the excitatory synapses...
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