Progressive neurochemical abnormalities in cognitive and motor subgroups of ALS: a prospective multicentre study

Daniel Ta, Abdullah Ishaque, Ojas Srivastava, Chris Hanstock, Peter Seres, Dean Eurich, Collin Luk, Hannah Briemberg, Richard Frayne, Angela Genge, Simon Graham, Lawrence Korngut, Lorne Zinman & Sanjay Kalra
Objective: To evaluate progressive cerebral degeneration in amyotrophic lateral sclerosis (ALS) by assessing alterations in N-acetylaspartate (NAA) ratios in the motor and prefrontal cortex within clinical subgroups of ALS. Methods: Seventy-six ALS patients and 59 healthy controls were enrolled a prospective, longitudinal, multicenter study in the Canadian ALS Neuroimaging Consortium (CALSNIC). Participants underwent serial clinical evaluations and MRS at baseline, 4 and 8 months using a harmonized protocol across 5 centers. NAA ratios were quantified...
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