Data from: Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis

Takashi Koyama, Marisa A. Rodrigues, Alekos Athanasiadis, Alexander W. Shingleton & Christen K. Mirth
Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition-dependent checkpoint, critical weight. Previous studies indicate that insulin/insulin-like growth factor signaling (IIS)/Target of Rapamycin (TOR) signaling in the prothoracic glands (PGs) regulates ecdysone biosynthesis and critical weight. Here we elucidate a mechanism through which this occurs. We show that...
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