Fatal outcome of chikungunya virus infection in Brazil

William Marciel Souza, Shirlene Telmos Silva De Lima, John Washington Cavalcante, Darlan Da Silva Candido, Marcilio Jorge Fumagalli, Jean-Paul Carrera, Leda Maria Simões Mello, Fernanda Montenegro De Carvalho Araújo, Izabel Letícia Cavalcante Ramalho, Francisca Kalline De Almeida Barreto, Deborah Nunes De Melo Braga, Adriana Rocha Simião, Mayara Jane Miranda Da Silva, Rhaquel De Morais Alves Barbosa Oliveira, Clayton Pereira Silva Lima, Camila De Sousa Lins, Rafael Ribeiro Barata, Marcelo Nunes Pereira Melo, Michel Platini Caldas De Souza, Luciano Monteiro Franco, Fábio Rocha Fernandes Távora, Daniele Rocha Queiroz Lemos, Carlos Henrique Morais De Alencar, Ronaldo De Jesus, Vagner De Souza Fonseca … & Fabio Miyajima
Abstract Background Chikungunya virus (CHIKV) emerged in the Americas in 2013 and has caused ~2.1 million cases and over 600 deaths. A retrospective investigation was undertaken to describe clinical, epidemiological and virus genomic features associated with deaths caused by CHIKV in Ceará state, northeast Brazil. Methods Sera, cerebrospinal fluid (CSF) and tissue samples from 100 fatal cases with suspected arbovirus infection were tested for CHIKV, dengue (DENV) and Zika virus (ZIKV). Clinical, epidemiological and death...
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