Data from: Large-effect mutations generate trade-off between predatory and locomotor ability during arms race coevolution with deadly prey

Michael T.J. Hague, Gabriela Toledo, Shana L. Geffeney, Charles T. Hanifin, , , Michael T. J. Hague & Edmund D. Brodie
Adaptive evolution in response to one selective challenge may disrupt other important aspects of performance. Such evolutionary trade-offs are predicted to arise in the process of local adaptation, but it is unclear if these phenotypic compromises result from the antagonistic effects of simple amino acid substitutions. We tested for trade-offs associated with beneficial mutations that confer tetrodotoxin (TTX) resistance in the voltage-gated sodium channel (NaV1.4) in skeletal muscle of the common garter snake (Thamnophis sirtalis)....
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