Pathogen-mediated selection favours the maintenance of innate immunity gene polymorphism in a widespread wild ungulate

Erwan Quéméré, Pauline Hessenauer, Maxime Galan, Marie Fernandez, Joël Merlet, Yannick Chaval, Nicolas Morellet, Hélène Verheyden, Emmanuelle Gilot-Fromont & Nathalie Charbonnel
Toll-like Receptors (TLR) play a central role in recognition and host frontline defence against a wide range of pathogens. A number of recent studies have shown that TLR genes (Tlrs) often exhibit large polymorphism in natural populations. Yet, there is little knowledge on how this polymorphism is maintained and how it influences disease susceptibility in the wild. In previous work, we showed that some Tlrs exhibit similarly high levels of genetic diversity as genes of...
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