Exposure to 3, 3’, 4, 4’, 5-pentachlorobiphenyl (PCB 126) causes widespread DNA hypomethylation in adult zebrafish testis

Neelakanteswar Aluru & Jan Engelhardt
Exposure to environmental toxicants during preconception have been shown to affect offspring health and epigenetic mechanisms such as DNA methylation are hypothesized to be involved in adverse outcomes. However, studies addressing the effects of exposure to environmental toxicants during preconception on epigenetic changes in gametes are limited. The objective of this study is to determine the effect of preconceptional exposure to a dioxin-like PCB (PCB126) on DNA methylation and gene expression in testis. Adult zebrafish...
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