Data from: All-optical recording and stimulation of retinal neurons in vivo in retinal degeneration mice

Soon Keen Cheong, Jennifer M. Strazzeri, David R. Williams & William H. Merigan
Here we demonstrate the application of a method that could accelerate the development of novel therapies by allowing direct and repeatable visualization of cellular function in the living eye, to study loss of vision in animal models of retinal disease, as well as evaluate the time course of retinal function following therapeutic intervention. We use high-resolution adaptive optics scanning light ophthalmoscopy to image fluorescence from the calcium sensor GCaMP6s. In mice with photoreceptor degeneration (rd10),...
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