Neurofilament light as a biomarker in traumatic brain injury

Pashtun Shahim, Adam Politis, Andre Van Der Merwe, Brian Moore, Yi-Yu Chou, Dzung Pham, John Butman, Ramon Diaz-Arrastia, Jessica Gill, David Brody, Henrik Zetterberg, Kaj Blennow & Leighton Chan
Objective: To determine whether serum neurofilament light (NfL) correlates with CSF NfL, traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor imaging (DTI) estimates of traumatic axonal injury (TAI). Methods: Participants were prospectively enrolled in Sweden and the United States between 2011 and 2019. The Swedish cohort included 45 hockey players with acute concussion sampled at 6 days, 31 with repetitive concussion with persistent postconcussive symptoms (PCS) assessed with paired CSF and...
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