Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

Johanne Egge Rinholm, Lauritz Hagen Kennedy, Emilie Rylund Glesaaen, Vuk Palibrk, Marco Pannone, Wei Wang, Ali Hussein Jafar Al-Jabri, Rajikala Suganthan, Niklas Meyer, Xiaolin Lin, Linda Hildegard Bergersen, Magnar Bjørås, Lauritz Kennedy, Emilie R Glesaaen, Ali Al-Jabri, Marie Landa Austbø, Linda H Bergersen & Johanne E Rinholm
Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that facilitate tissue repair after HI may aid the development of better treatments. Here, we study the role of lactate receptor HCAR1 in tissue repair after neonatal HI in mice. We show that HCAR1 knockout mice have reduced tissue regeneration compared with wildtype mice. Furthermore, proliferation of neural...
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