Data from: Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

Agustina D'Urso, Yoh-Hei Takahashi, Bin Xiong, Jessica Marone, Robert Coukos, Carlo Randise-Hinchliff, Ji-Ping Wang, Ali Shilatifard & Jason H. Brickner
In yeast and humans, previous experiences can lead to epigenetic transcriptional memory: repressed genes that exhibit mitotically heritable changes in chromatin structure and promoter recruitment of poised RNA polymerase II preinitiation complex (RNAPII PIC), which enhances future reactivation. Here, we show that INO1 memory in yeast is initiated by binding of the Sfl1 transcription factor to the cis-acting Memory Recruitment Sequence, targeting INO1 to the nuclear periphery. Memory requires a remodeled form of the Set1/COMPASS...
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