Data from: Experimental evolution of Legionella pneumophila in mouse macrophages leads to strains with altered determinants of environmental survival

Alexander W. Ensminger, Yosuf Yassin, Alexander Miron & Ralph R. Isberg
The Gram-negative bacterium, Legionella pneumophila, is a protozoan parasite and accidental intracellular pathogen of humans. We propose a model in which host cycling through multiple protozoan hosts in the environment holds L. pneumophila in a state of evolutionary stasis as a broad host-range pathogen. Using an experimental evolution approach, we tested this hypothesis by restricting L. pneumophila to growth within mouse macrophages for hundreds of generations. Whole-genome resequencing and high-throughput genotyping identified several parallel adaptive...
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