Low circulating levels of miR-451a in girls with Polycystic Ovary Syndrome: different effects of randomized treatments

Lourdes Ibanez, Marta Diaz, Judit Bassols, Abel Lopez-Bermejo & Francis De Zegher
Context: Polycystic ovary syndrome (PCOS) is a prevalent disorder in adolescent girls, purportedly driven by hepato-visceral fat excess, and often followed by subfertility and type 2 diabetes. Objective:we studied the baseline miRNA profile of girls with PCOS, and the effects of a randomized treatment with an oral contraceptive (OC) or with spironolactone-pioglitazone-metformin (SPIOMET, aiming at loss of hepato-visceral fat excess) for 1 year. Design & Patients:The miRNA profile was assessed by RNA sequencingin girls with...
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