Lack of statistical power as a major limitation in understanding MHC-mediated immunocompetence in wild vertebrate populations

Arnaud Gaigher, Reto Burri, Luis M. San-Jose, Alexandre Roulin & Luca Fumagalli
Disentangling the sources of variation in developing an effective immune response against pathogens is of major interest to immunoecology and evolutionary biology. To date, the link between immunocompetence and genetic variation at the major histocompatibility complex (MHC) has received little attention in wild animals, despite the key role of MHC genes in activating the adaptive immune system. Although several studies point to a link between MHC and immunocompetence, negative findings have also been reported. Such...
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