Data from: Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease

Eleonor Olsson, Christof Winter, Anthony George, Yilun Chen, Jillian Howlin, Man‐Hung Eric Tang, Malin Dahlgren, Ralph Schulz, Dorthe Grabau, Danielle Van Westen, Mårten Fernö, Christian Ingvar, Carsten Rose, Pär‐Ola Bendahl, Lisa Rydén, Åke Borg, Sofia K. Gruvberger-Saal, Helena Jernström & Lao H. Saal
Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it is rarely curable. Cell‐free circulating tumor DNA (ctDNA) contains tumor‐specific chromosomal rearrangements that may be interrogated in blood plasma. We evaluated serial monitoring of ctDNA for earlier detection of metastasis in a retrospective study of 20 patients diagnosed with primary breast cancer and long follow‐up. Using an approach combining low‐coverage whole‐genome sequencing of primary tumors and quantification of tumor‐specific rearrangements in plasma...
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