β-cell-specific deletion of Zfp148 improves nutrient-stimulated β-cell Ca2+ responses

Christopher Emfinger, Alan Attie, Matthew Merrins, Eleonora De Klerk, Matthias Hebrok, Richard Kibbey, Rebecca Cardone, Kathryn Schueler, Mary Rabaglia, Shane Simonett, Donnie Stapleton, Kelly Mitok, Sophie Lewandowski, Ziyue Wang, Christina Kendziorski, Mark Keller, Hannah Foster, Stephen Gygi, Xinyue Liu, Joao Paulo, Qinq Yu & José Perales
Insulin secretion from pancreatic β-cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β-cell-specific deletion of Zfp148 (β-Zfp148KO) improves glucose tolerance and insulin secretion in mice. Here, we performed Ca2+ imaging of islets from β‑Zfp148KO and control mice on both a chow and a Western-style diet. β-Zfp148KO islets demonstrate improved sensitivity and sustained Ca2+ oscillations in response to elevated glucose. β-Zfp148KO islets also...
1 citation reported since publication in 2021.
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