Longitudinal evidence for immunosenescence and inflammaging in free-living great tits

Martin Těšický, Tereza Krajzingrová, Zuzana Świderská, Kamila Syslová, Barbora Bílková, Jiří Eliáš, Hana Velová, Jana Svobodová, Petra Bauerová, Tomáš Albrecht & Vinkler Michal
The first-line effector mechanisms of immune defence, including inflammation and oxidative burst, contribute significantly to host-pathogen resistance. Whether these immune responses undergo age-related changes in birds remains unknown. Here, we tracked selected inflammatory parameters in 54 free-living great tits (Parus major) of known age, captured repeatedly over three consecutive years, with the aims to investigate long-term repeatability and age-dependent changes in cellular oxidative burst responsiveness upon in vitro stimulation with bacterial lipopolysaccharide (LPS), and to...
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2 downloads reported since publication in 2021.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?