Targeted lipidomics yields changes in both arachidonic acid and linoleic acid pathways observed in C57BL/6J mice compared to KitW-sh mice after nitrogen mustard exposure

Angela Cruz-Hernandez, Jared Brown, Ryan Mendoza, Kathleen Nguyen, Christopher Evans, Anna Harder, Alison Bauer & Neera Tewari-Singh
Sulfur mustard (SM) has been widely used as a chemical warfare agent including most recently in Syria. Mice exposed to SM exhibit an increase in pro-inflammatory cytokines followed by immune cell infiltration in the lung, however, the mechanisms leading to these inflammatory responses has not been completely elucidated. Mast cells are one of the first responding innate immune cells found at the mucosal surfaces of the lung and have been reported to be activated by...
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