Data from: Bypass of genetic constraints during mutator evolution to antibiotic resistance

Alejandro Couce, Alexandro Rodríguez-Rojas, Jesús Blázquez, A. Rodriguez-Rojas & J. Blazquez
Genetic constraints can block many mutational pathways to optimal genotypes in real fitness landscapes, yet the extent to which this can limit evolution remains to be determined. Interestingly, mutator bacteria elevate only specific types of mutations, and therefore could be very sensitive to genetic constraints. Testing this possibility is not only clinically relevant, but can also inform about the general impact of genetic constraints in adaptation. Here, we evolved 576 populations of two mutator and...
1 citation reported since publication in 2015.
106 views reported since publication in 2015.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?
19 downloads reported since publication in 2015.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?