Data from: Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

Patrícia A. Correia, Eran Lottem, Dhruba Banerjee, Ana S. Machado, Megan R. Carey & Zachary F. Mainen
Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a strong suppression of spontaneous locomotor behavior in the open field with rapid kinetics (onset ≤1 s). Inhibition of locomotion was independent of measures of anxiety or...
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