MCMC output files for: Quantitative characterization of population-wide tissue- and metabolite-specific variability in perchloroethylene toxicokinetics in male mice

Chimeddulam Dalaijamts, Joseph Cichocki, Yu-Syuan Luo, Ivan Rusyn & Weihsueh Chiu
Quantification of inter-individual variability is a continuing challenge in risk assessment, particularly for compounds with complex metabolism and multi-organ toxicity. Toxicokinetic variability for perchloroethylene (perc) was previously characterized across three mouse strains and in one mouse strain with various degrees of liver steatosis. To further characterize the role of genetic variability in toxicokinetics of perc, we applied Bayesian population physiologically-based pharmacokinetic (PBPK) modeling to the data on perc and metabolites in blood/plasma and tissues of...
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