Data from: Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila

Seth Tomchik, Lanikea King, Tamara Boto, Valentina Botero, Ari Aviles, Breanna Jomsky, Chevara Joseph & James Walker
Neurofibromatosis type 1 is a monogenetic disorder that predisposes individuals to tumor formation and cognitive and behavioral symptoms. The neuronal circuitry and developmental events underlying these neurological symptoms are unknown. To better understand how mutations of the underlying gene (NF1) drive behavioral alterations, we have examined grooming in the Drosophila neurofibromatosis 1 model. Mutations of the fly NF1 ortholog drive excessive grooming, and increased grooming was observed in adults when Nf1 was knocked down during...
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