Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface

Daniel J O'Shea, Eric Trautmann, Xulu Sun, Karl Deisseroth & Krishna Shenoy
Calcium imaging has rapidly developed into a powerful tool for recording from large populations of neurons in vivo. Imaging in rhesus macaque motor cortex can enable the discovery of new principles of motor cortical function and can inform the design of next generation brain-computer interfaces (BCIs). Surface two-photon (2P) imaging, however, cannot presently access somatic calcium signals of neurons from all layers of macaque motor cortex due to photon scattering. Here, we demonstrate an implant...
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