Differentiation of parathyroid hormone expressing cells from human pluripotent stem cells

Diane Krause, Betty R Lawton, Corine Martineau, Julie Ann Sosa, Sanziana Roman, Courtney E Gibson, Michael A Levine & Diane S Krause
Abstract Differentiation of pluripotent stem cells into functional parathyroid-like cells would accelerate development of important therapeutic options for subjects with parathyroid-related disorders, from the design and screening of novel pharmaceutical agents to the development of durable cellular therapies. We have established a highly reproducible directed differentiation approach leading to parathyroid hormone (PTH) expressing cells from human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC). We accomplished this through the comparison of multiple different...
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