Data from: Th2 cytokines inhibit lymphangiogenesis

Ira L. Savetsky, Swapna Ghanta, Jason C. Gardenier, Jeremy S. Torrisi, Gabriela D. Garcia Nores, Geoffrey E. Hespe, Matthew D. Nitti, Raghu P. Kataru & Babak J. Mehrara
Lymphangiogenesis is the process by which new lymphatic vessels grow in response to pathologic stimuli such as wound healing, inflammation, and tumor metastasis. It is well-recognized that growth factors and cytokines regulate lymphangiogenesis by promoting or inhibiting lymphatic endothelial cell (LEC) proliferation, migration and differentiation. Our group has shown that the expression of T-helper 2 (Th2) cytokines is markedly increased in lymphedema, and that these cytokines inhibit lymphatic function by increasing fibrosis and promoting changes...
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