Ageing as early-life inertia: disentangling life-history trade-offs along a lifetime of an individual

Edward Ivimey-Cook, Hanne Carlsson, Elizabeth Duxbury, Nathan Edden, Kris Sales & Alexei Maklakov
The theory that ageing evolves because of competitive resource allocation between the soma and the germline has been challenged by studies showing that somatic maintenance can be improved without impairing reproduction. However, it has been suggested that cost-free improvement in somatic maintenance is possible only under a narrow range of benign conditions. Here we show that experimental downregulation of insulin/IGF-1 signalling (IIS) in C. elegans nematodes, a robustly reproducible lifespan and healthspan-extending treatment, reduces fitness...
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1 download reported since publication in 2021.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
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