Data from: Ligation of glycophorin A generates reactive oxygen species leading to decreased red blood cell function

Joseph Khoory, Jessica Estanislau, Abdallah Elkhal, Asmae Lazaar, Mark I. Melhorn, Abigail Brodsky, Ben Illigens, Itaru Hamachi, Yasutaka Kurishita, Alexander R. Ivanov, Sergey Shevkoplyas, Nathan I. Shapiro & Ionita C. Ghiran
Acute, inflammatory conditions associated with dysregulated complement activation are characterized by significant increases in blood concentration of reactive oxygen species (ROS) and ATP. The mechanisms by which these molecules arise are not fully understood. In this study, using luminometric- and fluorescence-based methods, we show that ligation of glycophorin A (GPA) on human red blood cells (RBCs) results in a 2.1-fold, NADPH-oxidase-dependent increase in intracellular ROS that, in turn, trigger multiple downstream cascades leading to caspase-3...
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