Data from: Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins

James S. Ruff, Raed B. Saffarini, Leda L. Ramoz, Linda C. Morrison, Shambralyn Baker, Sean M. Laverty, Petr Tvrdik, Mario R. Capecchi & Wayne K. Potts
Here we assess the fitness consequences of the replacement of the Hoxa1 coding region with its paralog Hoxb1 in mice (Mus musculus) residing in semi-natural enclosures. Previously, this Hoxa1B1 swap was reported as resulting in no discernible embryonic or physiological phenotype (i.e., functionally redundant), despite the 51% amino acid sequence differences between these two Hox proteins. Within heterozygous breeding cages no differences in litter size nor deviations from Mendelian genotypic expectations were observed in the...
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