Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation

Roumen Parapanov, Xingyu Wang, Anne Debonneville, Jérôme Lugrin, Yabo Wang, Etienne Abdelnour, Michel Gonzalez, Jean Perentes, Fabrizio Gronchi, Philippe Eckert, Lise Piquilloud Piquilloud, Igor Letovanec, Thorsten Krueger & Lucas Liaudet
Ex vivo lung perfusion (EVLP) with pharmacological reconditioning may increase donor lung utilization for transplantation (LTx). 3-Aminobenzamide (3-AB), an inhibitor of poly (ADP-ribose) polymerase (PARP), reduces ex vivo lung injury in rat lungs damaged by warm ischemia (WI). Here we determined the effects of 3-AB reconditioning on graft outcome after LTx. Three groups of donor lungs were studied: Control (Ctrl): 1 hour WI + 3 hours cold ischemia (CI) + LTx; EVLP: 1 hour WI...
1 citation reported since publication in 2021.
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