Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans

Edward Ivimey-Cook, Kris Sales, Hanne Carlsson, Simone Immler, Tracey Chapman & Alexei Maklakov
Dietary restriction increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here we investigated the effect of dietary restriction by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in C. elegans. We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P0), it has a...
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5 downloads reported since publication in 2021.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
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