Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

Huiliang Zhang, Nathan Alder, Wang Wang, Hazel Szeto, David Marcinek & Peter Rabinovitch
Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population. However, the mechanisms of physiologic aging in general, and cardiac aging in particular, remain poorly understood. Age-related heart impairment is lacking a clinically effective treatment. Using the model of naturally aging mice and rats, we show direct evidence of increased proton leak in the aged heart mitochondria. Moreover, our data suggested ANT1 as the most likely site of mediating increased mitochondrial proton permeability in...
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