Gigantic genomes of salamanders indicate body temperature, not genome size, is the driver of global methylation and 5-methylcytosine deamination in vertebrates

Alexander Adams, Robert Daniel Denton & Rachel Lockridge Mueller
Transposable elements (TEs) are sequences that replicate and move throughout genomes, and they can be silenced through methylation of cytosines at CpG dinucelotides. TE abundance contributes to genome size, but TE silencing variation across genomes of different sizes remains underexplored. Salamanders include most of the largest C-values -- 9 to 120 Gb. We measured CpG methylation levels in salamanders with genomes ranging from 2N = ~58 Gb to 4N = ~116 Gb. We compared these...
1 citation reported since publication in 2022.
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