Data from: Does high-dose antimicrobial chemotherapy prevent the evolution of resistance?

Troy Day & Andrew F. Read
High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical studies have begun to challenge this view. We develop a very general framework for modeling and understanding resistance emergence based on principles from evolutionary biology. We use this framework to show how high-dose chemotherapy engenders opposing evolutionary processes involving the mutational input of resistant strains and their release from ecological competition. Whether such therapy provides the...
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11 downloads reported since publication in 2016.

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