Witnessed apneas are associated with elevated tau-PET levels in cognitively unimpaired elderly
Diego Carvalho, Erik St. Louis, Christopher Schwarz, Val Lowe, Bradley Boeve, Scott Przybelski, Ashritha Reddy, Michelle Mielke, David Knopman, Ronald Petersen, & Prashanthi Vemuri
Objective: To assess whether informant-reported apneas during sleep (witnessed apneas) in cognitively unimpaired (CU) elderly persons are associated with higher levels of brain tau. Methods: From the population-based Mayo Clinic Study of Aging, we identified 292 CU elderly aged >=65 years with both AV-1451 tau-PET and PiB-PET scans and whose bed partners and close relatives had completed a questionnaire that assessed whether participants had witnessed apneas during sleep. For this cross-sectional analysis, we selected the...
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