Data from: Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination

Mark D. Grier, Kathryn L. West, Nathaniel D. Kelm, Cary Fu, Mark D. Does, Brittany Parker, Eleanor McBrier, Andre H. LaGrange, Kevin C. Ess & Robert P. Carson
Myelin abnormalities are increasingly being recognized as an important component of a number of neurologic developmental disorders. The integration of many signaling pathways and cell types are critical for correct myelinogenesis. The PI3-K and mechanistic target of rapamycin (mTOR) pathways have been found to play key roles. mTOR is found within two distinct complexes, mTORC1 and mTORC2. mTORC1 activity has been shown to play a major role during myelination, while the role of mTORC2 is...
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