Differential ESR1 promoter Methylation in the peripheral blood of healthy middle-aged and older women- findings from the women 40+ healthy aging study

Elena Gardini, Gary G. Chen, Serena Fiacco, Laura Mernone, Jasmine Willi, Gustavo Turecki & Ulrike Ehlert
Background Estrogen receptor alpha (ERα) contributes to maintain biological processes preserving health during aging. DNA methylation changes of ERα gene (ESR1) were established as playing a direct role in the regulation of ERα levels. In this study, we hypothesized decreased DNA methylation of ESR1 associated with postmenopause, lower estradiol levels and increased age among healthy middle-aged and older women. Methods We assessed DNA methylation of ESR1 promoter region from dried blood spots and estradiol from...
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