Data from: Validation and utilization of amended diagnostic criteria in Creutzfeldt-Jakob Disease surveillance

Peter Hermann, Mareike Laux, Markus Glatzel, Jakob Matschke, Tobias Knipper, Stefan Goebel, Johannes Treig, Walter Schulz-Schaeffer, Maria Cramm, Matthias Schmitz & Inga Zerr
Objective: To validate an amended protocol for clinical diagnosis of sporadic Creutzfeldt-Jakob Disease (sCJD) including Real-Time Quaking-induced Conversion (RT-QuIC) and to observe its utilization in CJD surveillance. Methods: In the framework of a prospective epidemiological study, all neuropathological confirmed sCJD cases that received CSF RT-QuIC analysis during diagnostic work up (n=65) and a control group of non- CJD cases (n=118) were selected to investigate the accuracy of an amended diagnostic protocol. The patients had been...
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