Wild chimpanzees exhibit human-like aging of glucocorticoid regulation

Melissa Emery Thompson, Stephanie Fox, Andreas Berghaenel, Kris Sabbi, Sarah Phillips-Garcia, Drew Enigk, Emily Otali, Zarin Machanda, Richard Wrangham & Martin Muller
Cortisol, a key product of the stress response, has critical influences on degenerative aging in humans. In turn, cortisol production is affected by senescence of the hypothalamic-pituitary-adrenal (HPA) axis, leading to progressive dysregulation and increased cortisol exposure. These processes have been studied extensively in industrialized settings, but few comparative data are available from humans and closely-related species living in natural environments, where stressors are very different. Here, we examine age-related changes in urinary cortisol in...
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