Nanoscale binding site localization by molecular distance estimation on native cell surfaces using topological image averaging

Pontus Nordenfelt, Vibha Kumra Ahnlide, Johannes Kumra Ahnlide, Sebastian Wrighton & Jason Beech
Antibody binding to cell surface proteins plays a crucial role in immunity and the location of an epitope can altogether determine the immunological outcome of a host-target interaction. Techniques available today for epitope identification are costly, time-consuming, and unsuited for high-throughput analysis. Fast and efficient screening of epitope location can be useful for the development of therapeutic monoclonal antibodies and vaccines. The cellular morphology typically varies, and antibodies often bind heterogeneously across a cell surface,...
1 citation reported since publication in 2022.
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