Data from: Impaired spatial memory codes in a mouse model of Rett syndrome

Sara E. Kee, Xiang Mou, Huda Y. Zoghbi & Daoyun Ji
The Mecp2+/-mouse model recapitulates many phenotypes of patients with Rett syndrome (RTT), including learning and memory deficits. It is unknown, however, how the disease state alters memory circuit functions in vivoin RTT mice. Here we recorded from hippocampal place cells, which are thought to encode spatial memories, in freely moving RTT mice and littermate controls. We found that place cells in RTT mice are impaired in their experience-dependent increase of spatial information. This impairment is...
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