Data from: A mitochondrial progesterone receptor increases cardiac beta-oxidation and remodeling

Qunsheng Dai, Creighton E Likes, Anthony L Luz, Lan Mao, Jason S Yeh, Zhengzheng Wei, Maragatha Kuchibhatla, Olga R Ilkayeva, Timothy R Koves & Thomas M Price
Progesterone is primarily a pregnancy related hormone, produced in substantial quantities after ovulation and during gestation. Traditionally known to function via nuclear receptors for transcriptional regulation there is also evidence of non-nuclear action. A previously identified mitochondrial progesterone receptor (PR-M) increases cellular respiration in cell models. In these studies, we demonstrated that expression of PR-M in rat H9c2 cardiomyocytes resulted in a ligand-dependent increase in oxidative cellular respiration and beta-oxidation. Cardiac expression in a TET-On...
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