Data from: Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels

Jette Strasen, Uddipan Sarma, Marcel Jentsch, Stefan Bohn, Caibin Sheng, Daniel Horbelt, Petra Knaus, Stefan Legewie & Alexander Loewer
The cytokine TGFβ provides important information during embryonic development, adult tissue homeostasis and regeneration. Alterations in the cellular response to TGFβ are involved in severe human diseases. To understand how cells encode the extracellular input and transmit its information to elicit appropriate responses, we acquired quantitative time-resolved measurements of pathway activation at the single cell level. We established dynamic time warping to quantitatively compare signaling dynamics of thousands of individual cells and described heterogeneous single-cell...
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