Heterochromatin-dependent transcription of satellite DNAs in the Drosophila melanogaster female germline

Xiaolu Wei, Danna G. Eickbush, Iain Speece & Amanda M. Larracuente
Large blocks of tandemly repeated DNAs—satellite DNAs (satDNAs)—play important roles in heterochromatin formation and chromosome segregation. We know little about how satDNAs are regulated, however their misregulation is associated with genomic instability and human diseases. We use the Drosophila melanogaster germline as a model to study the regulation of satDNA transcription and chromatin. Here we show that complex satDNAs (>100-bp repeat units) are transcribed into long noncoding RNAs and processed into piRNAs (PIWI interacting RNAs)....
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