Demographic History and Genomic Targets of Positive Selection in Giant Gough Mice

Peicheng Jing & Bret Payseur
A key challenge in understanding how natural selection operates is to identify the mutations and genes that make it possible. Positive selection on beneficial mutations distorts linked variation by altering the site frequency spectrum, the configuration of haplotypes, and population differentiation. By comparing patterns of sequence variation to neutral predictions across genomes, the targets of positive selection can be located. We applied this logic to an unusual population of house mice that shows phenotypic and...
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