Data from: Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery

Ting Zhang, Ling Zhu, Michele Catherine Madigan, Wei Liu, Weiyong Shen, Svetlana Cherepanoff, Fanfan Zhou, Shaoxue Zeng, Jianhai Du & Mark Cedric Gillies
The human macula is more susceptible than the peripheral retina to developing blinding conditions such as age-related macular degeneration, diabetic retinopathy. A key difference between them may be the nature of their Müller cells. We found primary cultured Müller cells from macula and peripheral retina display significant morphological and transcriptomic differences. Macular Müller cells expressed more Phosphoglycerate Dehydrogenase (PHGDH, a rate-limiting enzyme in serine synthesis) than peripheral Müller cells. The serine synthesis, glycolytic and mitochondrial...
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