Data from: Plasticity and epistasis strongly affect bacterial fitness after losing multiple metabolic genes

Glen D’Souza, Silvio Waschina, Christoph Kaleta, Christian Kost & Glen D'Souza
Many bacterial lineages lack seemingly essential metabolic genes. Previous work suggested selective benefits could drive the loss of biosynthetic functions from bacterial genomes when the corresponding metabolites are sufficiently available in the environment. However, the factors that govern this ‘genome streamlining’ remain poorly understood. Here we determine the effect of plasticity and epistasis on the fitness of Escherichia coli genotypes from whose genome biosynthetic genes for one, two, or three different amino acids have been...
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