Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation

Henning J Falk, Takehito Tomita, Gregor Moenke, Katie McDole & Alexander Aulehla
A fundamental requirement for embryonic development is the coordination of signaling activities in space and time. A notable example in vertebrate embryos is found during somitogenesis, where gene expression oscillations linked to the segmentation clock are synchronized across cells in the presomitic mesoderm (PSM) and result in tissue-level wave patterns. To examine their onset during mouse embryo development, we studied the dynamics of the segmentation clock gene Lfng during gastrulation. To this end, we established...
1 citation reported since publication in 2022.
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