Data from: A liquid-like organelle at the root of motile ciliopathy

Ryan L. Huizar, Chanjae Lee, Alexander A. Boulgakov, Amjad Horani, Fan Tu, Edward M. Marcotte, Steven L. Brody & John B. Wallingford
Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus. While many patients harbor mutations in the dynein motors that drive cilia beating, the disease also results from mutations in so-called Dynein Axonemal Assembly Factors (DNAAFs) that act in the cytoplasm. The mechanisms of DNAAF action remain poorly defined. Here, we show that DNAAFs concentrate together with axonemal dyneins and chaperones into organelles that...
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