Intrinsic excitability mechanisms of neuronal ensemble formation

Tzitzitlini Alejandre-García, Samuel Kim, Jesús Pérez-Ortega & Rafael Yuste
Neuronal ensembles are coactive groups of cortical neurons, found in spontaneous and evoked activity, that can mediate perception and behavior. To understand the mechanisms that lead to the formation of ensembles, we co-activated optogenetically and electrically layer 2/3 pyramidal neurons in brain slices from mouse visual cortex, in animals from both sexes, replicating in vitro an optogenetic protocol to generate ensembles in vivo. Using whole-cell and perforated patch-clamp pair recordings we find that, after optogenetic...
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