Cleavage of SARS-CoV-2 spike protein mutants

Markus Hoffmann, Prerna Arora, Sidarovich Anzhalika, Luise Graichen, Bojan Hörnich, Alexander Hahn & Stefan Pöhlmann
Several SARS-CoV-2 variants emerged that harbor mutations in the surface unit of the viral spike (S) protein that enhance infectivity and transmissibility. Here, we analyzed whether ten naturally-occurring mutations found within the extended loop harboring the S1/S2 cleavage site of the S protein, a determinant of SARS-CoV-2 cell tropism and pathogenicity, impact S protein processing and function. None of the mutations increased but several decreased S protein cleavage at the S1/S2 site, including S686G and...
1 citation reported since publication in 2022.
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